Seroprevalence of Toxoplasma gondii in people at an increased risk of HIV infection – a pilot study

Abstract

<br><b>Introduction:</b> The observation of the epidemiology of toxoplasmosis may prevent the development of a severe form of the disease in HIV patients.</br> <br><b>Aim:</b> The aim of the study was to evaluate the seroprevalence of <i>Toxoplasma gondii</i> in the population of the Kuyavian-Pomeranian Voivodeship at high risk of contracting HIV.</br> <br><b>Material and methods:</b> Blood serum samples of 43 patients of the Consulting and Diagnostic AIDS Center were tested for the presence of anti-HIV-1/HIV-2 antibodies and p24 antigen, and for the presence of anti-toxoplasma IgM and IgG antibodies.</br> <br><b>Results:</b> Anti-toxoplasma IgG antibody prevalence of 53.5% (23/43) was found in the study population, while the examination of specific IgM antibodies was negative. A high IgG antibody avidity index was obtained in 18 (94.7%) seropositive samples. Thirty (69.77%) of the samples were female, and 13 (30.23%) were male. Among men, HIV was detected in 1 (7.69%), and IgG antibodies against <i>T. gondii</i> in 7 (53.85%) samples. IgG antibodies against <i>T. gondii</i> were found in 16 (53.33%) women. The HIV-positive individual was 24 years old. The presence of antibodies against <i>T. gondii</i> in the IgG class was found in people of different ages (in women aged 38.44 ±13.00 years old and in men aged 29.29 ±10.86 years old). The risky situation that could cause HIV infection is in most cases sexual contacts (79.07%).</br> <br><b>Conclusions:</b> High seroprevalence of <i>T. gondii</i> was found among the studied subjects at a high risk of HIV infection. Further research is required on a larger study group.</br>