Abstract
Rubella is a generally benign but dangerous viral infection in early pregnancy, due to the teratogenic potential of the virus. Indeed, it causes spontaneous abortions, in-utero fetal death, premature labor and congenital malformations known as congenital rubella syndrome. The purpose of this study is to determine the immune status of rubella in pregnant women in southern Morocco. A prospective, multicentre study was conducted in 2017 for the detection of rubella IgG and IgM antibodies in 380 pregnant women aged 17 to 46 years, using the Architect i1000 chemiluminescent microparticle immunoassay. Eigthy for percent (84.7%) of women were seropositive. Ten percent of multiparous women remained seronegative despite recommendations for vaccination after delivery. Preventive measures against congenital rubella need to be strengthened, and vaccination is needed in non-immunized women. Vaccination awareness campaigns, especially among non-immunized multiparous women, remain essential.
Highlights
Rubella is an acute viral disease, basically one of children
Rubella is a generally benign but dangerous viral infection in early pregnancy, due to the teratogenic potential of the virus. It causes spontaneous abortions, in-utero fetal death, premature labor and congenital malformations known as congenital rubella syndrome
When a woman contracts the disease during pregnancy, the consequences can be dramatic for the fetus, especially when the infection takes place in the first trimester, sometimes leading to spontaneous abortion, fetal death, or the birth of a child with congenital malformations known as Congenital rubella syndrome (CRS)
Summary
Rubella is an acute viral disease, basically one of children. Its clinical course is generally favorable in almost all cases when it affects the child in the postnatal period. It is, a real public health problem because of the teratogenicity of the virus. When a woman contracts the disease during pregnancy, the consequences can be dramatic for the fetus, especially when the infection takes place in the first trimester, sometimes leading to spontaneous abortion, fetal death, or the birth of a child with congenital malformations known as Congenital rubella syndrome (CRS). In Morocco, the epidemiology of rubella remains poorly understood, since it is not a reportable disease. This study has for its objectives the determination of the rubella immunity status of pregnant women in southern Morocco and the effort to establish a link between rubella seroprevalence and the socio-demographic factors studied
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