Abstract
Here we present mumps virus specific antibody levels in a large cross-sectional population-based serosurveillance study performed in the Netherlands in 2006/2007 (n = 7900). Results were compared with a similar study (1995/1996) and discussed in the light of recent outbreaks. Mumps antibodies were tested using a fluorescent bead-based multiplex immunoassay. Overall seroprevalence was 90.9% with higher levels in the naturally infected cohorts compared with vaccinated cohorts. Mumps virus vaccinations at 14 months and 9 years resulted in an increased seroprevalence and antibody concentration. The second vaccination seemed to be important in acquiring stable mumps antibody levels in the long term. In conclusion, the Dutch population is well protected against mumps virus infection. However, we identified specific age- and population groups at increased risk of mumps infection. Indeed, in 2007/2008 an outbreak has occurred in the low vaccination coverage groups emphasizing the predictive value of serosurveillance studies.
Highlights
Mumps was a common worldwide childhood disease before the introduction of routine vaccination in several countries
The administration of the second mumps and rubella virus (MMR) vaccination at the age of 9 years induced an increase in seroprevalence to 96%
Seroprevalence in the twice-vaccinated cohorts decreased gradually to 87% in the age group of 19–21 years
Summary
Mumps was a common worldwide childhood disease before the introduction of routine vaccination in several countries. In general it causes a relatively benign infection, but it can result in considerable morbidity including orchitis, deafness, meningitis and very rarely death [1]. In the Netherlands, a combination vaccine of measles, mumps and rubella virus (MMR) has been part of the national immunization program (NIP) since 1987. The MMR vaccine used in the NIP (BMR-VaccinH) was produced by the national institute for public health and the environment (RIVM) and later by the vaccine institute of the Netherlands (NVI) in license of MSD. Since 2008 it was replaced by PriorixH from GlaxoSmithKline. In the Netherlands, the MMR vaccine always contained the
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