Abstract
Levels of Japanese cedar pollen (Cryptomeria japonica) have increased in Japan and cedar pollinosis caused by Japanese cedar pollen has been reported in dogs. Serum levels of immunoglobulin E (IgE) against Cry j 1 and Cry j 2 in dogs raised in institutes and treated at veterinary hospitals in Japan were thus investigated. A total of 71 sera obtained from two institutes and 87 sera obtained from veterinary hospitals in the Hyogo and Kanagawa Prefectures were analyzed in this study. Serum levels of IgE were measured using the enzyme-linked immunosorbent assay with commercial purified Cry j 1 and Cry j 2. IgE against Cry j 1 and Cry j 2 in sera obtained from the two institutes were detected, despite the dogs being bred in enclosed areas. Moreover, significant differences were noted in the serum levels of IgE against Cry j 1 and Cry j 2 between the two institutes. The number of samples showing Cry j 1 or Cry j 2 levels above the cut-off values was greater in the Kanagawa Prefecture than in the Hyogo Prefecture. In total, 14 dogs showed Cry j 1 and Cry j 2 levels greater than the cut-off values in the Hyogo Prefecture, and only three such dogs were seen in the Kanagawa Prefecture. A significant correlation between serum levels against both allergens was observed (r2 = 0.6931, p < 0.0001).
Highlights
Numerous Japanese cedar (Cryptomeria japonica) trees were planted about 70 years ago, and the large number of trees aged 30 years or more has led to increased levels of cedar pollen in Japan [1,2].In humans, the incidence of seasonal allergic rhinitis and pollinosis in response to Japanese cedar pollen has increased [3,4,5,6]
Pollinosis caused by Japanese cedar pollen has been reported in dogs, and the incidence of atopic dermatitis in dogs sensitized to Japanese cedar pollen is reported to be about 10% [9,10,11,12,13]
The reason for immunoglobulin E (IgE) antibodies against Cry j 1 or Cry j 2 being present in dogs raised in enclosed areas was considered to be continuous exposure to Japanese cedar pollen through the air filter
Summary
The incidence of seasonal allergic rhinitis and pollinosis in response to Japanese cedar pollen has increased [3,4,5,6]. The prevalence of allergic rhinitis and cedar pollinosis caused by Japanese cedar pollen is reported to be 23.4% and 26.5%, respectively [6]. The symptoms of these conditions have reduced the quality of life in Japanese people [8]. Pollinosis caused by Japanese cedar pollen has been reported in dogs, and the incidence of atopic dermatitis in dogs sensitized to Japanese cedar pollen is reported to be about 10% [9,10,11,12,13]. Specific IgE against crude Japanese cedar pollen has been detected in about 20% of atopic dogs in
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