Abstract
A large majority of cervical cancer (more than 95%) is due to the Human Papillomavirus (HPV). The HPV type 16 account more than half of cervical cancers Worldwide. This study investigated the sero-prevalence of HPV-16 IgG antibodies among women attending General Hospital Kagarko, Kagarko Local government, Kaduna State. Serum samples and questionnaires were administered to 110 women for collection of data. HPV-16 specific IgG antibodies were detected by the use of an HPV-16 virus-like particle ELISA. The highest HPV-16 IgG sero-positivity 24.5% (27/110), was found at the age >20-59 years and at 95% confidence interval. Sero-positivity increased from 9.5% in women having one lifetime sex partner to 62.5% in women with more than three sex partners (p=0.006). Age at first intercourse, number of lifetime sex partners, and having had sex with men who have multiple sex partners were significantly associated with HPV-16 IgG antibodies. These information on HPV sero-epidemiology will be important for designing prevention efforts including vaccine programs.
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