Abstract
BackgroundRegular screening of transfusion-transmissible infections (TTIs), such as human immunodeficiency virus (HIV), hepatitis B and hepatitis C virus (HBV and HCV, respectively), and Treponema pallidum, in blood donors is essential to guaranteeing clinical transfusion safety. This study aimed to determine the seroprevalence of four TTIs among blood donors on Bioko Island, Equatorial Guinea (EG).MethodsA retrospective survey of blood donors from January 2011 to April 2013 was conducted to assess the presence of HIV, HBV, HCV and T. pallidum. The medical records were analyzed to verify the seroprevalence of these TTIs among blood donations stratified by gender, age and geographical region.ResultsOf the total 2937 consecutive blood donors, 1098 (37.39%) had a minimum of one TTI and 185 (6.29%) harbored co-infections. The general seroprevalence of HIV, HBV, HCV and T. pallidum were 7.83%, 10.01%, 3.71% and 21.51%, respectively. The most frequent TTI co-infections were HBV-T. pallidum 60 (2.04%) and HIV-T. pallidum 46 (1.57%). The seroprevalence of HIV, HBV, HCV and T. pallidum were highest among blood donors 38 to 47 years, 18 to 27 years and ≥ 48 years age, respectively (P<0.05). The seroprevalence of TTIs varied according to the population from which the blood was collected on Bioko Island.ConclusionsOur results firstly provide a comprehensive overview of TTIs among blood donors on Bioko Island. Strict screening of blood donors and improved hematological examinations using standard operating procedures are recommended.
Highlights
Blood donation save millions of lives worldwide each year [1]
The seroprevalence of human immunodeficiency virus (HIV), HBV, HCV and T. pallidum were highest among blood donors 38 to 47 years, PLOS ONE | DOI:10.1371/journal.pone
Our results firstly provide a comprehensive overview of transmissible infections (TTIs) among blood donors on Bioko Island
Summary
Blood transfusion plays an essential role in the supportive care of medical patients, unsafe transfusion practices lead to the persistence of transfusion-transmissible infections (TTIs), including human immunodeficiency virus (HIV), hepatitis B and C virus (HBV and HCV, respectively), Treponema pallidum, arboviruses, malaria, filariasis and occasionally diseases such as toxoplasmosis and brucellosis [2,3]. According to the World Health Organization (WHO) recommendations, all blood donations should be screened for HIV, HBV, HCV and T. pallidum. Regular screening of transfusion-transmissible infections (TTIs), such as human immunodeficiency virus (HIV), hepatitis B and hepatitis C virus (HBV and HCV, respectively), and Treponema pallidum, in blood donors is essential to guaranteeing clinical transfusion safety. This study aimed to determine the seroprevalence of four TTIs among blood donors on Bioko Island, Equatorial Guinea (EG)
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