Abstract
BackgroundBlood transfusion is one of the routine therapeutic interventions in hospitals that can be lifesaving. However, this intervention is related to several transfusion-related infections. Hepatitis C viral infection is one of the most common causes of transfusion-related hepatitis. Subsequently, this systematic review and meta-analysis was aimed to estimate the seroprevalence of hepatitis C virus infection among blood donors in Ethiopia.MethodsPubMed, Google Scholar, Health InterNetwork Access to Research Initiative (HINARI), Excerpta Medica database (EMBASE), and Cochrane library, the web of science, African journal of online (AJOL), and Google Scholar was searched. The data were extracted using Microsoft Excel and analyzed by using STATA version 14. Publication bias was checked by funnel plot, contour-enhanced funnel plots, trim and fill analysis and more objectively through Egger’s regression test, with P < 0.05 considered to indicate potential publication bias. The heterogeneity of studies was checked using I2 statistics. Pooled analysis was conducted using a weighted inverse variance random-effects model. Subgroup analysis was done by region and study period. A sensitivity analysis was employed.ResultA total of 25 studies with 197,172 study participants were used to estimate the seroprevalence of hepatitis c virus among blood donors. The overall seroprevalence of hepatitis C virus was 0.819% (95% CI: 0.67–0.969; I2 = 92.3%). Regional sub-group analysis showed that the pooled prevalence of hepatitis c virus infection among blood donors found to be 0.563% in Somali, 1.08% in Oromia, 0.847% in Amhara, and 0.908% in south nations nationalities and peoples region.ConclusionThe pooled seroprevalence of hepatitis C virus infection among blood donors in Ethiopia found to be low. Moreover, there should be systematic strategies that enhance donor screening and retention of safe regular donors.
Highlights
Blood transfusion is one of the routine therapeutic interventions in hospitals that can be lifesaving
Unless the donated blood screened systematically, each transfused patient will have a chance of getting transfusion-transmittable diseases human immunodeficiency virus (HIV), hepatitis B virus, hepatitis C virus and syphilis [2]
Hepatitis c virus is one of the common serious transfusion-transmittable contaminations which require genuine consideration during blood transfusion. Avoidance of this viral infection in developed nations accomplished by avoiding unnecessary transfusions, using regular blood donors, barring donors with specific risk factors and orderly screening all sorts of blood that will be given
Summary
Blood transfusion is one of the routine therapeutic interventions in hospitals that can be lifesaving. This intervention is related to several transfusion-related infections. The World Health Organization (WHO), to assure the quality and safety, recommends screening of donated blood for a minimum of the major transfusiontransmittable infections, including human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis [2]. Ethiopian national blood bank was set up in 1969. Unless the donated blood screened systematically, each transfused patient will have a chance of getting transfusion-transmittable diseases HIV, hepatitis B virus, hepatitis C virus and syphilis [2]
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