Abstract
Objectives: To determine the seroprevalence of HBsAg in the local population in and around Vizianagaram(Andhra Pradesh )from April 2003 – Oct 2010 ; to compare the prevalence of seropositivity of HBsAg with other regions in India ; to compare the prevalence of HBsAg positivity in voluntary and replacement donors. Materials and methods: A retrospective study was conducted on blood donors over a period of 7yrs to assess the prevalence of hepatitis B virus infection. Hepacard , which uses the principle of one step immunoassay was used for screening the donors. Results: A retrospective study was carried on 8601 blood donors out of which 2560(29.76%) were voluntary donors and 6401(70.24%) were replacement donors .The prevalence of HBsAg seropositivity in replacement donors was found to be 2.45% ; in voluntary donors 2.54% and overall prevalence was estimated to be 2.48% . The prevalence of HBsAg positivity was not found to be significant among voluntary and replacement donors donors( p > 0.05) . Whereas a significant result was observed in voluntary group over the study period (p < 0.001). Conclusion: The increasing prevalence of HBsAg can be reduced by more sensitive screening assays and proper donor selection.
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