Abstract
Background and aims: The hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are associated with major public health concerns. The aim of the study was to determine the seroprevalence of HBV, HCV and HIV in the western region of Nepal.Methods: This was a cross-sectional observational study, in which 15,791 patients, attending to Manipal Teaching Hospital, Pokhara, Nepal, were investigated for HBV, HCV and HIV from June 2013 to March 2016; demographic and biochemical profile were studied among the patients with positive test results.Results: Among 15,791 patients [male 6614 (41.9%) and female 9177 (58.1%)], HBV was found in 180 (1.1%), HCV in 52 (0.3%) and HIV in 77 (0.5%). The HBV was found in 63.9% of males and 36.1% of females, HCV in 67.3% of males and 32.7% of females, and HIV in 61% of males and 39% of females which showed that males had more positivity of HBV (P<0.001), HCV (P<0.001) and HIV (P 0.001) than that of female. The HBV was found more in 20-29 years age group (27.2%), HCV in 30-39 years (32.7%), and HIV in 40-49 years (28.6%), with all having p<0.001. Among the patients of HBV, HCV and HIV, the mean values of total bilirubin were 1.4 mg/dl, 0.8 mg/dl and 2.6 mg/dl, Aspartate Transaminase 75.9 U/L, 54.3 U/L and 92.7 U/L, Alanine Transaminase 54.6 U/L, 55.5 U/L and 56.1 U/L, and Alkaline Phosphatase 124.2 U/L, 109.2 U/L and 107.2 U/L, respectively. The majority of patients with HCV had a history of intravenous drug abuse and HIV had concomitant alcoholic liver disease.Conclusion: The HBV was more prevalent followed by HIV and HCV in the western region of Nepal with more prevalence seen in males than in females. Regular screening of HBV, HCV and HIV among the selected patients can help detecting many new cases in Nepal.Journal of Advances in Internal Medicine 2016;05(01):6-10
Highlights
Hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are the three most common chronic viral pathogens of major public health concerns having similar routes of transmission, such as blood and bloodThe hepatitis B virus (HBV) and HCV infection lead to chronic liver diseases, especially cirrhosis and hepatocellular carcinoma.[3]
HBV was found in 63.9% of males and 36.1% of females [Odds Ratio (OR) 1.54, 95% Confidence Interval (CI) 1.37 – 1.72, P
The HBV was found in 63.9% of males and 36.1% of females, HCV in 67.3% of males and 32.7% of females, and HIV in 61% of males and 39% of females which showed that males had more positivity of HBV [Odds Ratio (OR) 1.54, 95% Confidence Interval (CI) 1.37 – 1.72, P
Summary
Hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are the three most common chronic viral pathogens of major public health concerns having similar routes of transmission, such as blood and bloodThe HBV and HCV infection lead to chronic liver diseases, especially cirrhosis and hepatocellular carcinoma.[3]. Hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are the three most common chronic viral pathogens of major public health concerns having similar routes of transmission, such as blood and blood. Viral hepatitis B and hepatitis C are significant global health issues. It is estimated that about 2 billion people are exposed to hepatitis B worldwide, with 350 million suffering from chronic infection. More than 200 million people are estimated to be suffering from chronic infection with hepatitis C throughout the world. Hepatitis B is estimated to result in 563,000 deaths annually versus 366,000 deaths for hepatitis C worldwide.[3]. The hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are associated with major public health concerns. The aim of the study was to determine the seroprevalence of HBV, HCV and HIV in the western region of Nepal
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