Seroprevalence of Hepatitis B, Hepatitis C, Syphilis, Human Immunodeficiency Virus and Co-infections among Antenatal Women in a Tertiary care Hospital, Uttar Pradesh, India

Kiran Yadav,Prakash Kumar Mishra,Preeti Verma,Suresh Kumar Yadav,Sanjeev Kumar Tripathi

doi:10.22207/jpam.16.1.40

Abstract

Sexually transmitted infections (STI) associated with pregnancy poses a great threat to fetal well being due to vertical transmission. This study was conducted to determine the seroprevalence of hepatitis C virus, hepatitis B virus, HIV and syphilis infection in pregnant women. This retrospective study was conducted in Microbiology department over a period of one year from December 2018 to December 2019 at a tertiary care teaching hospital, Uttar Pradesh, India. In this study, hepatitis B surface antigen (HBsAg), antibodies against hepatitis C virus, HIV and syphilis infection were detected in antenatal women. Total 4037 pregnant women attending antenatal clinic were enrolled in this study. The seroprevalence of HBV was 1.34% (54/4037), HCV was 0.52% (21/4037), syphilis was 0.07% (3/4037), and HIV was 0.12% (5/4037). Only one patient had coinfection of HBV and HCV. Regular antenatal screening of all pregnant females for various infections should be done for proper and timely intervention.

Highlights

Transmitted infections (STI) associated with pregnancy poses a great threat to fetal well being due to vertical transmission
Hepatitis B surface antigen (HBsAg), antibodies against hepatitis C virus, HIV and syphilis infection were detected in antenatal women
A total of 4037 samples from pregnant women were tested for HIV, HBV, Hepatitis C virus (HCV) and syphilis infection

Summary

Introduction

Associated with pregnancy such as HIV, HBV, HCV and syphilis poses a great threat to fetal well being due to vertical transmission. Hepatitis B infection is very common and important throughout the World. There is an estimated prevalence of 387 million of HBV infected people with approximate 10 million persons getting infected each year.[1] There are three major routes for transmission of this virus – vertical, horizontal and sexual.[2] Hepatitis B infection during pregnancy is associated with high rate of vertical transmission which may result in fetal and neonatal hepatitis. The HBV infection acquired in early childhood has high probability to later develop into carrier state and chronic diseases with lethal complications like liver cirrhosis and hepatocellular carcinoma in adults.[3]

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Results

Conclusion