Abstract
Background: The World Health Organization recommends universal and quality-controlled screening of blood donations for the major transfusion-transmissible infections (TTIs): human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis. The magnitude of transfusion-transmitted infections (TTI) varies from country to country depending on TTI’s load in that particular population. The present study was undertaken to determine the relative proportion of voluntary donors (VDs) and replacement donors (RDs) and also, to estimate and compare the seroprevalence and changing trends of TTIs amongst VDs and RDs in a tertiary care medical hospital in north India. Methods: This retrospective study was based on the records of all voluntary and replacement donations whichwere collected from January 2016to August 2018 in atertiary care medical college and hospital in Bareilly, Uttar Pradesh, India. Results:Of the total 7908 donations, 2268 (28.6%) were voluntary and 5640 (71.4%) werereplacement donation. The overall seroprevalence of TTI was 158 (1.9%) out of total 7908 donations, with prevalence ofhepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV), were 1.0, 0.8 and 0.1 percent, respectively. Furthermore, the TTIs were more frequently encountered in RDs in comparison to VDs. Conclusions: The potential risk of TTIS can be curtailed to a large extent by increasing in public awareness regarding voluntary blood donation, donor screening using stringent criteria, counselling anduse of highly sensitive and specific tests.
Highlights
Blood transfusion implies the process of receiving blood or blood products into one's circulation intravenously
Samples were collected in vacutainers at the time of blood donation and screened for human immunodeficiency virus (HIV) 1-2, HBs Ag and hepatitis C virus (HCV) using fourth-generation enzyme-linked immunosorbent assay (ELISA) technique, using kits manufactured by Avantor (Bene Sphera, USA) and steps performed according to kit inserts
Further on analysing TTIS amongst voluntary donors (VDs) and replacement donors (RDs) as shown in Table 3, amongst donors, hepatitis B virus (HBV) turned out to be the most prevalent transmissible infections (TTIs) and the seropositivity for VD and RD were comparable in year wise category with marked difference note in 2017 HCV cases, with 0.7% seropositivity in VD and 1.8 % in RD.,prevalence of HBV in 2018 in VD was 1.8%, compared to 0.4 % in RD
Summary
Blood transfusion implies the process of receiving blood or blood products into one's circulation intravenously. The World Health Organization recommends universal and quality-controlled screening of blood donations for the major transfusion-transmissible infections (TTIs): human immuno deficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis. The present study was undertaken to determine the relative proportion of voluntary donors (VDs) and replacement donors (RDs) and to estimate and compare the seroprevalence and changing trends of TTIs amongst VDs and RDs in a tertiary care medical hospital in north India. Methods: This retrospective study was based on the records of all voluntary and replacement donations whichwere collected from January 2016to August 2018 in atertiary care medical college and hospital in Bareilly, Uttar Pradesh, India. The overall seroprevalence of TTI was 158 (1.9%) out of total 7908 donations, with prevalence ofhepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV), were 1.0, 0.8 and 0.1 percent, respectively. Conclusions: The potential risk of TTIS can be curtailed to a large extent by increasing in public awareness regarding voluntary blood donation, donor screening using stringent criteria, counselling anduse of highly sensitive and specific tests
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