Abstract

BackgroundHand, foot, and mouth disease has become very common in mainland of China in recent years, and enterovirus A71 and coxsackievirus A16 are its major etiologic factors. Here we investigated the seroprevalence of enterovirus A71 and coxsackievirus A16 based on a large group of healthy individuals in Shandong province, China.MethodsA total of 1378 healthy individuals were tested for serum neutralizing antibodies against enterovirus A71 and coxsackievirus A16 using a micro neutralization test.ResultsThe overall seroprevalence of enterovirus A71 neutralizing antibodies was 74.75%. It increased significantly from 48.84% in children aged 0–1 years old to 88.64% in those aged 20–29 years (p < 0.01) and decreased to 85.71% in adults > 40 years old with a significant gender-specific difference (p < 0.01). The overall coxsackievirus A16 antibody prevalence was 71.77%. It increased significantly from 39.53% in children aged 0–1 years to 80.68% in those aged 10–19 years (p < 0.01) and decreased to 75.63% in adults >40 years without a gender-specific difference. Nearly 50% of the children <1 year were susceptible to enterovirus A71 infection versus 40% to coxsackievirus A16 infection. Sample collection time and place also played a role in the enterovirus A71 and coxsackievirus A16 positive rates. The overall rates in January were significantly lower than those in April and August (p < 0.01); enterovirus A71 positive rates in Jinan city (capital city of Shandong province) were lower than those in Jining city and Zibo city (p < 0.05); and oxsackievirus A16 positive rates in Jining city were significantly higher than those in Jinan city and Zibo city (p < 0.01).ConclusionThere were significant differences among age groups, locations, and time points in the seroprevalence rates of enterovirus A71 and coxsackievirus A16 neutralizing antibodies in healthy people in Shandong province.

Highlights

  • Hand, foot, and mouth disease (HFMD) was first reported in New Zealand in 1957, and human enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16), members of the Picornaviridae family that were first isolated in 1958 and 1969, respectively [1], are the two major causative agents of HFMD that rarely cause acute neurological symptoms [2,3,4]

  • 50% of the children

  • In mainland of China, owing to a large number of deaths during a short period, HFMD emerged as a serious public health problem since a large HFMD outbreak associated with subgenotype C4 of EV-A71, started in Shandong province, China, in 2007 [9], and spread throughout the country; in 2008, HFMD was classified as a category C notifiable infectious disease by the Ministry of Health in China

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Summary

Background

Foot, and mouth disease has become very common in mainland of China in recent years, and enterovirus A71 and coxsackievirus A16 are its major etiologic factors. We investigated the seroprevalence of enterovirus A71 and coxsackievirus A16 based on a large group of healthy individuals in Shandong province, China

Results
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Discussion

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