Abstract
Objective: Cytomegalovirus (CMV) is a well-known virus with major consequences in growing fetus, premature infants, and immune deficient individuals. There are few reports in prevalence of CMV infection in Iran, mainly in pregnant women. We conducted an epidemiological study to investigate the age-stratified seroprevalence and epidemiological characteristics of CMV infection in total inhabitants of Isfahan state, central Iran. Methodology: In a cross sectional study 595 serum samples which were collected randomly from total population of Isfahan state, Iran were used for IgG anti-CMV antibody titration by a commercial enzymelinked immunosorbent assay (ELISA) kit. Data were analyzed by Statistical Package for Social Sciences for Windows version 15(SPSS). Chi-squar and Fisher exact tests were applied to determine antibody status in different age, gender, education, family member, and residency groups. Results: The overall prevalence was 98.2 %( 586/595). The prevalence in age groups of 6-9, 10-19, 20-29, 30-39, 40-49 and above 49 years were 95.7, 98.6, 97.8, 100, 96.6, and 100 percent respectively. There was no statistical significant association between CMV seroprevalence with age, gender, education, family member, and residency groups (P < 0.05). Conclusions: This study elucidates a very high prevalence of CMV infection in population which acquired it from early childhood. So it is necessary to initiate measures to reduce the burden of CMV disease in fetuses, premature infants, and immune deficient individuals. To treat hearing loss in inapparent congenitally infected infants, repeated auditory exams up to 5 years old has paramount importance.
Highlights
Cytomegalovirus (CMV) is the largest member of the Herpesviridae family with several strains and universal distribution.[1]
Primary CMV infection is usually asymptomatic, but the virus remains latent in many organs including kidney, lung, gastrointestinal tract, and genitourinary system.[1]
T-cell immunodeficent individuals mainly fetuses, premature infants, transplant recipients, and HIV patients are at high risk for acquiring serious CMV disease involving any organs certainly liver, pancreas, adrenals, lymph nodes, brain, eyes, heart, skin, genitourinary, and gastrointestinal systems.[1]
Summary
Cytomegalovirus (CMV) is the largest member of the Herpesviridae family with several strains and universal distribution.[1] The humans are the only reservoir and transmission occurs by direct or indirect contact with secretions of the infected people. Cytomegalovirus infection in Isfahan, Iran or reactivated disease. T-cell immunodeficent individuals mainly fetuses, premature infants, transplant recipients, and HIV patients are at high risk for acquiring serious CMV disease involving any organs certainly liver, pancreas, adrenals, lymph nodes, brain, eyes, heart, skin, genitourinary, and gastrointestinal systems.[1] In contrast, humoral immunity has less significant role in protection against CMV infection and mainly lessens severity of the related symptoms and serves as a marker of previous infection.[1]
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