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Abstract
Cytomegalovirus cause viral congenital infection at any stage of pregnancy leading to congenital defects, which can either be primary or recurrent and hearing loss is one of the common congenital CMV infection occurring in 10-15% of infected children. This study, therefore examined the seroprevalence of cytomegalovirus among paediatric patients with hearing loss attending National Ear Care Centre Kaduna northwest Nigeria. A total of 77 samples was collected from patients aged between 0-13 years, diagnosed of hearing impairment and screened for Cytomegalovirus IgG and IgM specific antibodies using ELISA method at National Ear Care Centre Kaduna State North West Nigeria. Among the 77 (100%) patients screened, 35 (45.5%) were male, while 42 (54.5%) were female with mean age (2.04). The study reveavled that, of the total numbers screened, 62 (80.5%) were IgG specific antibodies positive, while 15 (19.5%) were IgG specific antibodies negative, and none of the patient were positive for IgM specific antibodies. the result of patients based on their gender status show male patients 21 (60%) were positive while 14 (40%) were negative for CMV IgG specific antibodies. The female is 33 (78.5%) positive and 9 (21.4%) negative for CMV IgG specific antibodies. The findings hearing impairment is associated with cytomegalosvirus showing statistically significant in IgG specific antibodies (P<0.05), while in IgM it is not statistically significant. Therefore CMV infection is prevalent among patients with Hearing impairment and affect the social economic and political status of the patients.
Highlights
Cytomegalovirus is a member of the Herpes family, which is responsible for a wide range of infections in human of all ages
Congenital seizures disorder account for 10% of babies born with symptomatic CMV infection and it is a very common abnormality associated with CMV infections
Samples were analyzed for the presence of IgG/IgM antibodies using the Enzyme Linked Immunosorbent Assay (ELISA) according to manufacturer's instruction made by
Summary
Cytomegalovirus is a member of the Herpes family, which is responsible for a wide range of infections in human of all ages. Hearing loss is one of the common congenital CMV infection occurring in 10-15% of infected children [20, 21, 22, 23]. This has lead to screening for hearing of newborn babies, which has been recognized as an essential component of public health care of Childhood in developed countries. Congenital seizures disorder account for 10% of babies born with symptomatic CMV infection and it is a very common abnormality associated with CMV infections It is usually associated with children severely affected with sytomatic CMV infections of the nervous system. The seizure is ovious at birth and can be present at any time within six months of life and the severity varies from child to child, described as mild, moderate, or severe [8]
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