Abstract
Background information: HBV infection is a serious health problem and a leading cause for morbidity and mortality. Objective: To determine HBV markers ((Anti-HBcore (IgM), Anti-HBcore (IgG), HBsAb, HBsAg, and HBeAg)) among Village Midwifes in Khartoum State, Sudan, 2014. Method: It is a cross sectional study where 335 village midwives were surveyed. A pre-tested close ended questionnaire was used for demographic data. Five ml of venous blood was collected; sera were separated and stored at-20° centigrade for Eliza testing. All specimens were tested for Anti-HBcore (IgM), Anti-HBcore(IgG) and HBsAb. Positive specimens for Anti-HBcore were tested for HBsAg and positive specimens for HBsAg were tested for HBeAg. Data was analyzed by using statistical package of social sciences (SPSS) version (16). Z-test for single proportion was used to compare between the actual prevalence of HBV markers and the expected rates in the absence of risk. P value equal or less than 0.05 was considered statistically significant value. Result: Positive Anti-HBcore (IgG) accounted to 113 (34%), positive HBsAgwas 57 (57%), and positive HBsAb was 7%. The results were significant at 5% confidence level, since all P-values were less than 0.001. There was no positive HBeAgto express high infectivity rate or Anti-HBcore (lgM) to reflect acute infection rate among the respondents. Conclusion: Infection rate of HBV was high, while the related immunity was low among Village Midwives in Khartoum State, Sudan.
Highlights
Background InformationHBV infection is a serious health problem and a leading cause for morbidity and mortality
Data was analyzed by using statistical package of social sciences (SPSS) version (16); Z-test for single proportion was used to compare between the actual prevalence of HBV markers and the expected rates in the absence of risk
This study showed that the prevalence of Anti-HBcore (IgG), an indicator for past or ongoing infection among this group of midwives was 34% which was less than the prevalence of HBV infection rate among health workers in Uganda, 2003 where a prevalence of Anti-HBcore is 59.3% among midwives [14]
Summary
HBV infection is a serious health problem and a leading cause for morbidity and mortality. In Sudan, positive Anti-HBcore reported to be 47% - 78%, and HBsAg 6.8% - 26% [6]. Positive HBsAg was reported in 70% of women of child bearing age in Gezira State in Central Sudan [4]. In a study of HBV markers among HCWs in Public Teaching Hospitals in Khartoum State, Sudan, the prevalence of Anti-HBc, HBsAg, HBsAb, and HBeAg is 57%, 6%, 37% and 9% respectively;while that of Anti-HBcore total among midwives equal 73.3%. In a community base study in Um Zukra village in Gezira State in Sudan; Anti-HBcore is positive in 47.5% of the respondents [12]. To our knowledge no published studies were conducted among Village Midwifes in Khartoum State, Sudan. This study will provide information about seroprevalence of HBV markers among Village Midwifes in Khartoum State
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