Abstract
The aim of this study was to know the relationship between the human cytomegalovirus and diabetes mellitus through detection of human cytomegalovirus (HCMV) infection in diabetic patients in Kirkuk governorate by screening of anti-human cytomegalovirus IgM and IgG antibodies in the serum of diabetic patients by using of Immunochromatography and detection of IgG by ELISA technique in blood samples . Blood samples collected from 82 diabetic women patients and 10 samples from healthy looking with out diabetic women .The results of this study by Immunochromatography method detected in 22 samples (26.82%) IgM only ,25(30.48%) samples IgG only and 2(2.43%) samples showed positive results for both IgM and IgG for HCMV . In contrast, the results of control group were negative for anti-HCMV IgM and IgG antibodies in both Immunochromatography and ELISA technique. ELISA technique was used to know the presence IgG of HCMV for detection the sensitivity and specificity of Immunochromatography compared with ELISA technique . KeyWords : HCMV, Immunochromatography ,Diabetics,ELISA,
Highlights
Cytomegalovirus is a viral genus of the Herpesviruses group: in humans it is commonly known as human cytomegalovirus (HCMV) or Human Herpesvirus 5 (HHV-5) [1] .Human Cytomegalovirus (CMV) is a herpes virus and the most common cause of congenital viral infection and malformation in the developed countries resulting from viral intrauterine infection [2,3,4] .Cytomegalovirus like all herpes viruses undergoes latency and reactivation in the host
The frequency of infection ranges from 50% to 90% in general adult population, and varies with socio-economic level and to some extent, geographic location[11] .Human Cytomegalovirus (CMV) is the most common cause of congenital malformation in developed countries its clinical manifestations range from asymptomatic infection to severe fetal damage[12].Up to 15% of intrauterine CMV infections result in symptomatic congenital disease at birth and 10 to 15%of those born with asymptomatic congenital CMV will develop significant clinical squeal in infancy [13]
The presence of CMVspecific Immunoglobulin M (IgM) may not be indicative of primary infection, since it is produced during reactivation and re infection[14] .Some researchers showed significant relation between CMV infection and spontaneous abortion [15] .Ninety percent of infants with congenital CMV infection display no clinical manifestations at birth, the remaining 10% of intrauterine CMV infections resulting into signs at birth and they are at serious risk of long-term neurological squeal
Summary
Cytomegalovirus (from the Greek cyto-, "cell", and -megalo-, "large") is a viral genus of the Herpesviruses group: in humans it is commonly known as HCMV or Human Herpesvirus 5 (HHV-5) [1] .Human Cytomegalovirus (CMV) is a herpes virus and the most common cause of congenital viral infection and malformation in the developed countries resulting from viral intrauterine infection [2,3,4] .Cytomegalovirus like all herpes viruses undergoes latency and reactivation in the host. Viral activity can be observed in all organs, including the pancreas [7] demonstrating that the virus has a broad cellular tropism This broad cellular tropism is because widely spread receptors, such as integrin's and the epidermal growth factor receptor, serve as entry receptors [8,9]. The frequency of infection ranges from 50% to 90% in general adult population, and varies with socio-economic level and to some extent, geographic location[11] .Human Cytomegalovirus (CMV) is the most common cause of congenital malformation in developed countries its clinical manifestations range from asymptomatic infection to severe fetal damage[12].Up to 15% of intrauterine CMV infections result in symptomatic congenital disease at birth and 10 to 15%of those born with asymptomatic congenital CMV will develop significant clinical squeal in infancy [13]. All pregnant women who are complaining from other causes of abortion were excluded from study
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