Abstract
Abstract The specificity of the serologic reactions of benzene derivatives has been investigated with a rather large number of substances. Recently Berger and Erlenmeyer (1) have examined a serum got by using an azoprotein made from 3-amino pyridine and their results would seem to indicate that in this case less specific antibodies are formed than are obtained with benzene derivatives. In order to investigate further this question we have prepared antisera against two pyridine amino carboxylic acids as well as against 3-amino pyridine. The behavior of these antisera with related antigens and the inhibitory effect of related haptens on the precipitation with the homologous antigen have been studied and the results are recorded in this paper. Technic. Preparation of haptens and inhibitors. 3-amino-4-carboxy pyridine and 4-amino-3-carboxy pyridine. Cinchomeronic acid was prepared by the oxidation of isoquinoline using a method essentially that of Hoogewerff and van Dorp (2).
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