Abstract
Systematic examination of the cross-reactions of anti- b-locus allotype alloantisera, both qualitatively and quantitatively has led to the construction of a ‘map’ of the serological relationships between b4, b5, b6 and b9. The main features of this ‘map’ are minimal between b5 and b6 and maximal distances between b4 and b9. The other distances lie between these two extremes. Since the b6 allotype has the most in common with every other allotype and b9 has the least, the b6 antigen and anti-b6 are most frequently involved in cross-reactions whereas b9 and anti-b9 are involved the least. This information leads to the conclusion that for the most specific anti- b-locus allotype anibodies, the recipients of choice are heterozygous b 5 b 6 for anti-b4- and anti-b9, b 4 b 6 for anti-b5 and b 4 b 5 for anti-b6.
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