Abstract
Rheumatoid Arthritis (RA) is an autoimmune based inflammatory pathology with involvement of joints that show early morning stiffness alongwith pain resulting in loss of function. It usually affects females aged 30 years or above. A total of 150 patients of Rheumatoid Arthritis were included in the present study of which 120 were females and 30 males (F:M=4:1). Serological tests were carried out in these patients. These test were analyzed for their sensitivity as well as specificity. Combination of various test were also assessed for their results. In the present, study age and sex of patient affected by Rheumatoid arthritis was analysed. Combination of serological tests provided a high specificity as can be seen from the present study. Quantitative Rheumatoid factor estimation and Anti Rheumatoidantibodies assay gave the maximum specificity of 89.8%. A combination of serological tests is advisable rather than a single diagnostic test.This allows for the early diagnosis of Rheumatoid Arthritis so as to prevent complications by the disease. Keywords: Investigations, Rheumatoid Arthritis, Serology, Specificity, Sensitivity.
Highlights
Rheumatoid arthritis (RA) has a prevalence of about 0.5% to 1% and an incidence of about 30 per 100 000 inhabitants, making it one of the commonest chronic inflammatory autoimmune disease.[1,2,3] Rheumatoid arthritis (RA) is an inflammatory autoimmune pathology involving joints mainly leading to pain, early morning stiffness and restriction of movements
All patients included in the study were subjected to all the investigations such as complete haemogram, Erythrocyte sedimentation rate (ESR), Quantitative C-Reactive protein (CRP), Rheumatoid Factor (Latex as well as quantitative), and Anti cyclic variant of a citrullinated peptide (CCP) Antibodies (Anti-cyclic citrullinated peptide)
We studied the sensitivity and specificity of different serological markers as well as their combinations (Table 3)
Summary
Rheumatoid arthritis (RA) has a prevalence of about 0.5% to 1% and an incidence of about 30 per 100 000 inhabitants, making it one of the commonest chronic inflammatory autoimmune disease.[1,2,3] Rheumatoid arthritis (RA) is an inflammatory autoimmune pathology involving joints mainly leading to pain, early morning stiffness and restriction of movements. Diagnosis and aggressive treatment are the best means of avoiding joint destruction, damage to organs and disability. Studies on the spectrum and expression of RA in Asian population are limited in the literature.[5,6,7]. This prospective study was carried out to determine the relationship between RA and laboratory tests used in the diagnosis of RA.Traditionally females are affected about three to four times more often than men
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