Serological profile of hepatitis B in children after the introduction of its vaccination in Burkina Faso.

Makoura Barro,Abdoul Salam Ouedraogo,Diane Valea,Saga Alain Ouermi,Bintou Sanogo,Ibrahim Ad Bafa Ouattara,Boubacar Nacro,Georges Moyen,Sanata Sessouma

doi:10.4081/pr.2019.8248

Abstract

Viral hepatitis B is a public health issue. We establish the children serological profile of hepatitis B in Bobo-Dioulasso, six years after the introduction of hepatitis B vaccine into the Expanded Program on Immunization. This was a descriptive study of prospective data collection carried out in the Department of Pediatrics and the laboratory of virology of the Centre MURAZ of Bobo-Dioulasso between March 2013 and May 2013. Blood samples were made in search of the following hepatitis B serological markers: anti-HBcAb total, HBsAg, Ac anti-HBs, HBeAg, AcHBs, IgM anti-HBc total. The ELISA method with the Monolisa BIORAD reagents was used. A total of 2015 children were included, 1026 (50, 9%) boys and 989 (49.1%) girls, at an average age of 58±48 months. Out of these 2015 children, 53 (2.6%) were positive to HBsAg including 19 vaccinated cases, one child has received 3 doses plus 1 booster dose of hepatitis B vaccine. We found no statistically significant difference in the carriage of serologic markers of hepatitis B between the unvaccinated group and the vaccinated group. Large-scale studies should be carried out in Burkina Faso to see the real impact of vaccination on the health of our populations.

Highlights

The hepatitis B virus (HBV), part of the hepadnaviridae family, is a small genome of partially double strandled, partially single strangled circular DNA
The aim of our study is to establish the serological mapping of hepatitis B in children at the Pediatrics Department of Sourô Sanou University Hospital Bobo-Dioulasso, six years after the lected clinical data for this manuscript and did the literature research
We found no statistically significant difference in the carriage of serologic markers of hepatitis B between the unvaccinated group and the vaccinated group

Summary

Introduction

The hepatitis B virus (HBV), part of the hepadnaviridae family, is a small genome of partially double strandled, partially single strangled circular DNA. The markers of infection with the virus are the “s” antigens. (HBsAg), they are the surface antigens, the Key words: Hepatitis B, prevalence, children, Sanata Sessouma,[2] Bintou Sanogo,. “c” antigens (HBcAg) and the “e” (HBeAg) serological profile, Bobo-Dioulasso. Ibrahim Ad Bafa Ouattara,[1] Abdoul Salam Ouedraogo,[4] Boubacar Nacro,[1] Georges Moyen[5]

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