Abstract
Aims: Hepatitis B virus (HBV) infection is still a worldwide public health problem despite regular vaccination programs around the world. This study was performed to investigate the serological pattern of vaccinated subjects against recombinant repeatedly isolates of hepatitis B virus surface mutants, and evaluate the characteristics of HBsAg positive patients having HBs antibodies concurrently. Methods: Fifty vaccinated health care staffs participated in this study accompanied with five patients simultaneously carry HBsAg and anti-HBs antibody. For all the samples, the anti-HBs Enzyme-linked immunosorbent assay was performed for detecting antibody against thirteen recombinant mutants. Findings: The results showed that all vaccinated individuals had clinically sufficient protective antibody values (greater than 10 MIU/ml) with the mean value of 165 mIU/ml ± 29 mIU/ml. whereas, only 30% of individuals showed the complete protective neutralizing immune response to all specific HBsAg recombinant mutants. The lack of responsiveness mainly observed in three of HBV mutants; D144A (70%), Q129R (48.5%) and G145R (ad) (30%) respectively. The HBV chronic carriers with anti-HBs showed having the Q129R, G145R (ay), D144A, T126 N, T126s and G145 (ad) escaped mutants. Conclusion: The lack of responsiveness to some specific HBV mutants in vaccinated subjects, point out the potential risk of exposure to hepatitis B virus mutants.
Highlights
Hepatitis B virus (HBV) is a major etiologic agent of liver infection worldwide
Hepatitis B virus is considered moderately endemic in Iran with 3% of the population having evidence of chronic HBV infection [3]
The hepatitis B surface antigen (HBsAg); found on the surface of the virus is classified into 8 genotypes (A-H) and 9 serological subtypes
Summary
Hepatitis B virus (HBV) is a major etiologic agent of liver infection worldwide. The HBV is classified in Hepadnaviridae family and own a semicircular double stranded DNA molecule [1].Despite vaccinations, hepatitis B virus (HBV) infections are still very common worldwide. Hepatitis B virus (HBV) is a major etiologic agent of liver infection worldwide. The HBV is classified in Hepadnaviridae family and own a semicircular double stranded DNA molecule [1]. Hepatitis B virus (HBV) infections are still very common worldwide. It has been demonstrated that approximately 2 billion people globally are affected to The HBV [2]. Hepatitis B virus is considered moderately endemic in Iran with 3% of the population having evidence of chronic HBV infection [3]. The hepatitis B surface antigen (HBsAg); found on the surface of the virus is classified into 8 genotypes (A-H) and 9 serological subtypes. It is reported that genotype D is the predominant HBV genotype in the middle east and in Iran especially subtype ayw2 [5,6]
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