Abstract
IntroductionThe aim of this study was to evaluate a cut-off point of the titration of IgG by ELISA in the diagnosis of mumps. MethodsA study was made of serum samples from 85 mumps cases (confirmed by PCR in saliva) and 2351 controls of the general population of the Region of Madrid. ResultsThe IgM detection was positive in 21 cases (sensitivity of 24.7%). The best cut-off point corresponded to IgG titres≥4900 (sensitivity of 64.7% and specificity of 86.1%). Among 42 patients immunised with at least one dose of measles mumps, rubella vaccine IgM was detected in 4 cases. However, the detection of IgG≥4900 was positive in 29 (sensitivity of 69.0%). ConclusionsAn IgG result of ≥4900 was almost 5 times more probable in a patient with mumps than in a non-infected patient. The detection of high titres of IgG against mumps could improve the IgM results in vaccinated people.
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