Abstract
Background: Helicobacter pylori is a major gastroduodenal pathogen and its seropositivity is associated with increased risk of development of human active chronic gastritis, peptic and duodenal ulcer and gastric cancer. Objectives: The aim of this study was to determine the seroprevalence of H. pylori infection among subjects with gastrointestinal problems. Methods: From May 2014 to October 2014, a seroprevalence study was carried out among 100 subjects who had clinical gastric symptoms, with a mean age of 37.77 years (range, 2 to 70 years). Serum samples collected from 44 male and 56 female were screened for detection of anti H. pylori IgG using commercial DIAQUICK Helicobacter pylori (manufactured by DIALAB Production, GMBH) kit. Statistical analyses were performed using SAS software, version 9.1 (SAS Institute Inc., Cary, NC). Results: The overall seropositivity rate of anti H. pylori IgG was 53%. Seropositivity of anti H. pylori IgG increased markedly with age and highest infection rate (96%) was seen in individuals 40 to 50 years old. Anti H. pylori IgA was also correlated with increasing age. Analysis of results for gender showed that there were no significant differences in seropositivity to H. pylori between men and woman (p>0.05) but there was a significant correlation between anti H. pylori IgG and age of subjects (p<0.01). Analysis of results for inflammatory markers (WBC and ESR) showed normal mean of WBC count(7000 cells/ml) and ESR rate (8mm/h) levels in these subjects. No association was detected between H. pylori seropositivity, gender and inflammatory laboratory parameters. Conclusion: This study revealed the high prevalence of H. pylori infection among symptomatic subjects in the study area suggesting necessity of screening for H. pylori infection in symptomatic patients. The results also did not show any strict relations between H. pylori seropositivity, gender and inflammatory markers.
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