Abstract
The chikungunya virus (CHIKV) is spread by Aedes aegypti and Ae. albopictus mosquitos worldwide; infection can lead to disease including joint pain, fever, and rash, with some convalescent persons experiencing chronic symptoms. Historically, CHIKV transmission has occurred in Africa and Asia, but recent outbreaks have taken place in Europe, Indonesia, and the Americas. From September to October 2014, a survey was undertaken with nomadic pastoralists residing in the northeast departments of Senegal. Blood dried on filter paper (dried blood spots; DBS) were collected from 1465 participants of all ages, and assayed for Immunoglobulin G (IgG) antibodies against CHIKV E1 antigen by a bead-based multiplex assay. The overall seroprevalence of all participants to CHIKV E1 was 2.7%, with no persons under 10 years of age found to be antibody positive. Above 10 years of age, clear increases of seroprevalence and IgG levels were observed with increasing age; 7.6% of participants older than 50 years were found to be positive for anti-CHIKV IgG. Reported net ownership, net usage, and gender were all non-significant explanatory variables of seropositivity. These data show a low-level historical exposure of this pastoralist population to CHIKV, with no evidence of recent CHIKV transmission in the past decade.
Highlights
The chikungunya virus (CHIKV) belongs to the genus Alphavirus, and is transmitted to humans primarily by Aedes aegypti and Ae. albopictus mosquitos, it has been found in other mosquitos [1,2,3,4]
Immunoglobulin G (IgG) responses are known to occur to CHIKV E1 and E2 antigens, which are attractive for identified in Senegal in the 1960s [16,17], with defined outbreaks occurring in serological studieswas
We present seroprevalence estimates in the current report, one limitation to our study is that the nomadic pastoralist population is, by definition, a mobile population, and any previous CHIKV
Summary
The chikungunya virus (CHIKV) belongs to the genus Alphavirus (family Togaviridae), and is transmitted to humans primarily by Aedes aegypti and Ae. albopictus mosquitos, it has been found in other mosquitos [1,2,3,4]. Besides attempting to identify persons with active infection, seroepidemiological studies have shed light on individual- and population-level exposure to CHIKV, with the added. Recent presence in Senegal both by active viremia studies have been conducted in the relatively tropical and sparsely populated southeastern and serological evidence [19,20,22]. As of early 2019, no published studies be identified had in investigated population to epidemiological studies of infectious disease exposure in Senegalese nomadic. Populations nomadic pastoralists were sampled in Senegal in 2014 for. Populations of of nomadic pastoralists were sampled in Senegal in 2014 for an an integrated seroepidemiological study.
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