Abstract
The complement fixation test was found to be both sensitive and specific for detecting antibodies to Aspergillus fumigatus . Sera from active cases of histoplasmosis, coccidioidomycosis, blastomycosis, cryptococcosis and healthy subjects failed to elicit any reactions against aspergillin. Application of the test to sera from 21 cases of aspergillosis revealed antibodies in 14 active cases only. Of 92 sera assayed for antibodies by the complement fixation and immuno-electrophoretic tests, there was approximately 92 per cent agreement between the tests. Two cases which were initially detected by the complement fixation test only subsequently developed precipitins or were proved by culture. Thus, the complement fixation test provided a means of early provisional diagnosis.
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