Abstract
The present work is concerned with the ability of three commercial vaccines (A=whole; B=split; S=subunit) and an experimental vaccine (A-EV=low content of antigen) to induce in 304 persons with and without immunological experience towards influenza A/U.S.S.R.90/77 (N 2N 1) virus, antibodies against influenza hemagglutinin and neuraminidase. The data from this randomised double blind trial confirm that the response to influenza vaccines is strongly influenced by the previous contact of the population with influenza viruses of the past years. An age related seroconversion response to all vaccines has been observed: lower in the 25 yr of age group, higher in the group over 25 yr of age. As far as the H 1N 1 antibodies in unprimed persons are concerned the whole virus vaccines induced a higher GMT titer (1 : 52 and 1 : 48 (A-EV)), respectively as the split (1: 33) or the subunit vaccine (1: 10). All the vaccines produced a satisfactory NI seroconversion factor. The experimental vaccine (A-EV) gave good results comparable with those induced by the commercial vaccines.
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