Abstract
Cercariae of Schistosoma mansoni were observed in sera from uninfected hamsters, mice, rats, rabbits and guinea pigs, and from S. mansoni-infected hamsters, mice and rats. 1. 1. All sera from rats, rabbits and guinea pigs were strongly cercaricidal. Mouse and hamster sera were essentially non-cercaricidal. 2. 2. Precipitate formation usually accompanied cercaricidal activity. 3. 3. Cercaricidal activity and precipitate formation did not appear to be related to schistosome infection in these hosts. 4. 4. All the infected host sera were CHR positive, cercaricidal sera, however, only after heat-inactivation. 5. 5. Agglutination has been related to stickiness either of orally secreted material or of slowly developing membranes. 6. 6. CHR or pericercarial membrane formation was an acquired reaction to the presence of either sex of living worms or schistosomula in the mice, rats, and hamsters studied. It was not completely thermostable, but was storage stable. It was found only around living cercariae. Cercariai exhaustion with respect to the CHR was demonstrated, but serum exhaustion was not. 7. 7. Possible diagnostic value of the CHR in unisexual or latent infections is suggested.
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