Abstract
The aim of the study was the evaluation of frequency and titre of IgA ASCA and IgG ASCA and p-ANCA, c-ANCA in children with IBD and occurrence of ASCA antibodies in relation to coexistence of FA. Patients and methods. The study comprised 95 children at the ages of 2 to 18 years. The diagnosis of IBD was established on the basis of Porto criteria. Tests of blood serum were performed in all children: IgA and IgG ASCA, p-ANCA, c-ANCA using ELISA method. Results. IgE-dependent FA was found in 32.5% children with UC and in 21% with CD. We did not observe any relation between the occurrence of FA and the frequency and ASCA titre. p-ANCA were significantly more frequent in the group of children with UC. The occurrence of ASCA antibodies was observed in 73.7% of children with CD, 17.5% with UC and almost 30% with allergic colitis. Conclusions. Patients with CD and the presence of ASCA revealed a significantly more frequent localization of lesions within the small bowel and a tendency towards older age. We observed a connection between the occurrence of antibodies and the examined mutations of gene NOD2/CARD15.
Highlights
In the recent years we have observed an increased incidence of Inflammatory Bowel Disease, especially Crohn’s disease in children, and other, less frequent in this age group, types of colitis, including allergic colitis
We did not find statistically significant differences in the occurrence of food allergy in children with ulcerative colitis and Crohn’s disease, it is noticeable that atopy (IgE total) occurs more often in children with Crohn’s disease, and allergy to particular foods is more frequent among children with ulcerative colitis
We did not find the influence of food allergy on the clinical picture of ulcerative colitis; we observed a tendency towards a more frequent occurrence of inflammatory changes in the duodenum with inflammatory infiltration consisting of lymphocytes, plasmatic cells and eosinophils in patients with Crohn’s disease and food allergy
Summary
In the recent years we have observed an increased incidence of Inflammatory Bowel Disease, especially Crohn’s disease in children, and other, less frequent in this age group, types of colitis, including allergic colitis. Allergic colitis is a rare type of inflammation occurring in the course of IgE-mediated or IgE-independent food allergy, more frequently it affects children. This disease occurs in two age groups: in infancy or during puberty and in young adults. In the case of allergic colitis of adult type, clinical symptoms depend on the degree of intensity and the localization of inflammation—the predominant symptoms are those that are typical for Inflammatory Bowel Disease—chronic diarrhea, abdominal pain, loss of weight, and lack of appetite [1, 2]. In the case of a big intensity of eosinophilic infiltration we call the disease eosinophilic colitis [3]
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