Abstract
BackgroundToxoplasmosis is caused by the Toxoplasma gondii parasite. The parasite is intracellular and can result in severe complications leading to death in immuno-deficient patients in particular. Diabetes is an important factor that increases susceptibility and risk of various infections in the host.ObjectivesThe present study focused on the serologic detection of Toxoplasma gondii infection in diabetic patients.Materials and MethodsThrough a case-control study, overall 184 serum samples including 91 from diabetic cases and 93 from healthy non-diabetic controls were investigated. Cases and controls were matched for age and gender. Serum samples were tested for sugar by an enzymatic method, and IgG antibodies were tested against Toxoplasma gondii by ELISA method.ResultsThe prevalence of IgG antibodies against Toxoplasma gondii in diabetic patients and healthy controls were 60.43% and 38% respectively. Risk of toxoplasmosis infection in diabetic patients with was two folds higher than healthy controls (RR = 2.21, 95% CI; 1.6 – 3.7, P = 0.001).ConclusionsDiabetes may be caused by Toxoplasma gondii. Presence of T. gondii in the pancreas at the same time could directly undermines the pancreas cells. When β cells are destroyed, insulin secretion would then be affected. Probably the destruction of T. gondii affects nervous system and damages pancreatic cells leading to increased risk of diabetes.
Highlights
Toxoplasmosis is caused by the Toxoplasmagondii parasite
The present study shows correlation diabetes and toxoplasmosis
The present study aimed to investigate the effects of Toxoplamasis on uncontrolled diabetes and on the level of outbreak of infection in patients, depending on age, with differing immune systems and dietary habits
Summary
Toxoplasmosis is caused by the Toxoplasmagondii parasite. The parasite is intracellular and can result in severe complications leading to death in immuno-deficient patients in particular. Results: The prevalence of IgG antibodies against Toxoplasma gondii in diabetic patients and healthy controls were 60.43% and 38% respectively. Risk of toxoplasmosis infection in diabetic patients with was two folds higher than healthy controls (RR = 2.21, 95% CI; 1.6 – 3.7, P = 0.001). The destruction of T. gondii affects nervous system and damages pancreatic cells leading to increased risk of diabetes. The important role played by CD8 T cells in control of Toxoplasma gondii infection [4]. The APC presents pathogen-derived antigens and provides the appropriate signals to T cells to cause their activation. This activation leads to the proliferation, differentiation, and acquisition of effectors functions of the antigen-specific CD8 T cell.
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