Abstract
BackgroundPrimary ovarian insufficiency (POI) is heterogeneous disease defined by amenorrhea or premature depletion of ovarian follicles before the age of 40 years. The etiology of POI is still unclear. The purpose of this study is to evaluate whether women with POI have an elevated serum levels of autoimmunologic parameters.MethodsThe serum from peripheral blood samples which come from 96 POI patients and 100 age-matched health women were analyzed for a series of autoimmune antibodies using protein microarray. The antibodies to double-stranded DNA (ds-DNA), histone (HIS), nuclear ribonucleoprotein (RNP), Sjogren’s syndrome A (SSA/Ro), Sjogren’s syndrome B (SSB/La) and Smith antigen, Jo-1, scleroderma-associated antigen (Scl-70) and centromere (CEN), zona pellucid (ZP), adrenocortical antibodies (ACA),Rheumatoid factor (RF), glomerular basement membrane (GBM), proliferating cell nuclear antigen (PCNA), myeloperoxidase (MPO), proteinase 3 (PR3), thyroid microsomal antibody and antinuclear antibody (ANA)were analyzed.ResultsAmong the 96 women with POI and 100 age-matched health controls, women with POI had significantly elevated circulation levels of Jo-1 and PR3 (p = 0.010 and p = 0.001) whereas circulation levels of ANAs, dsDNA, histone, RNP, Sm, Scl-70, SSA, SSB, CEN, ZP, ACA, RF, GBM, PCNA, MPO and TM antibodies were similar between the two groups.ConclusionsThis study shows that the autoimmune antibodies JO-1 and PR3 were significantly higher in POI women group which suggested that these antibodies may have played special role in POI, but the evaluation of the exact pathways of them remains to be determined.
Highlights
Primary ovarian insufficiency (POI) is heterogeneous disease defined by amenorrhea or premature depletion of ovarian follicles before the age of 40 years
Among the 96 patients, 9 patients had histories of Mumps, 5 patients had histories of tuberculosis, 4 patients had histories of thyroid disorders and 2 patients had histories of diabetes mellitus. 10 of the patients presented with primary amenorrhea, 86 patients presented with secondary amenorrhea
When a cutoff value was used, the number of positive proteinase 3 (PR3) and Jo-1 antibody were significantly higher in women with POI (15/96 & 3/100, p = 0.002 and 12/96 & 3/100, p = 0.012) whereas the circulation levels of antinuclear antibody (ANA), dsDNA, Single-stranded DNA (ssDNA), histone, RNP, Smith antigen (Sm), Scleroderma-associated antigen (Scl-70), CEN, zona pellucid (ZP), AC, Rheumatoid factor (RF), glomerular basement membrane (GBM), proliferating cell nuclear antigen (PCNA), MPO and Thyroid microsomal (TM) antibodies were similar between the two groups
Summary
Primary ovarian insufficiency (POI) is heterogeneous disease defined by amenorrhea or premature depletion of ovarian follicles before the age of 40 years. The etiology of POI is still unclear. The purpose of this study is to evaluate whether women with POI have an elevated serum levels of autoimmunologic parameters. Early menopause occurs approximately 1% of women before 40 years of age, approximately 0.1% of women under 30 and 0.01% of women younger than 20. This condition is termed as premature ovarian failure (POF), referred to as primary ovarian insufficiency (POI), characterized by amenorrhea, sex steroid deficiency and elevated levels of gonadortropins.
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