Abstract
In case cross-reactivity against the 2009 pandemic in- fluenza virus is indeed due to infections caused by the Spanish influenza and /or its immediate descendant viruses in the late 1910s and the 1920s, this would seem to suggest that specific anti-influenza immunity can last for an extremely long time, even a lifetime. A recent study showing the existence of B cells clones specific for the Spanish influenza HA in the elderly, in- dicate that immunological memory may last a whole lifetime (9). Among the 400 post-pandemic specimens tested, the seroprevalence was 34,5% (n=138), while 53,6% of them were females. The mean age of the se
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