Sero-epidemiological evaluation of rubella immunity among pre-marriage women in Iran

Abstract

ABSTRACT Few studies have addressed the seroepidemiological profile of rubella among a representative population of young adult women. This study aims to determine the immunity and susceptibility rate against rubella in a representative population of women in reproductive age in Iran through serological evaluation. This cross-sectional study was conducted in 2012 on 804 pre-marriage women in Iran. Multi-stage random sampling was used for choosing study sample. Serologic test were used to assess subjects’ immunity to rubella and their titers of IgG antibody against rubella with ELISA method was measured. In total, 98.4% (95% CI: 97.5% −99.2%) of study participants were immune against rubella. Five women (0.6%) were in borderline category and 1% (8 women) was susceptible to rubella. The proportion of immune people in low and high incidence regions was 99.3% (95% CI: 97.8–99.9%), and 97.5% (95% CI: 96.4–98.5%), respectively (P = 0.05). Our data indicated that level of immunity to rubella in women of reproductive age in Iran is satisfactory. This finding indicates the achievement of Iran to the goal of high level of serum immunity against rubella among young women.