Abstract
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. Following infection, antibodies are formed against the spike (S) and nucleocapsid (N) proteins, which are the primary viral antigens of SARS-CoV-2. This study aims to determine the antibody response three weeks post-infection and its persistence. To study antibody responses in COVID-19-positive individuals and to compare the degree of antibody response in symptomatic and asymptomatic individuals. The persistence of the antibody response was also assessed. Adult patients (> 15 years of age) who were diagnosed as COVID-19-positive by RT-PCR, three weeks after swab positivity were tested for total antibody levels against COVID-19 antigens by electrochemiluminescence assay. Out of 226 individuals, 129 were symptomatic and 97 were asymptomatic. Among the 129 symptomatic individuals, 74 exhibited an antibody response, whereas in the asymptomatic individuals, only 10 exhibited an antibody response. The antibody response was found to be significant in symptomatic individuals compared to that in asymptomatic individuals (p < 0.05). All follow-up individuals were seropositive at the end of both 6 and 8 months. Antibodies against SARS-CoV-2 persist for 8 months following infection. Despite the waning of antibodies against the nucleocapsid antigen, there was no complete disappearance of antibodies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
