Sero-surveillance of SARS-CoV2 infection among health-care workers: A protocol

Abstract

Introduction: The objectives of the present survey are to estimate the seroprevalence and sero-conversion of SARS CoV2 among the health-care workers (HCWs) in health-care establishments and to analyze the various characteristics (risk factors) associated with SARS CoV-2 infection with the overall aim to generate evidence for planning and preventive measures in the Armed Forces. Methodology: Eight hospitals have been chosen based on the hospital admission rates of COVID-19 patients and local epidemiological situation of COVID-19 prevalent in the region. A total of 3800 HCWs would be enrolled in the cross-sectional survey. For longitudinal study, 1000 personnel would be followed up at 3 and 6 months. Population proportion to size would be used for enrolment at various stages. A validation study is inbuilt in the study. From each site, a nodal officer would be designated for facilitating. Real-time data monitoring and quality checks would be done. Sero-surveillance would be done using ELISA-based immunoglobulin antibody. Results: The present study would provide the estimates of seroprevalence and rate of seroconversion among the HCWs. The factors associated with seroprevalence and seroconversion would be delineated. Discussion: The protocol lays down the plan of action to implement the multi-centric serosurveillance project. The survey will provide an assessment of seroprevalence of COVID-19 infection among the health-care workers of hospitals of central ministry from the various parts of the country and its trend over a period of time.