Sero-Epidemiological Study of Hepatitis E Virus among Thalassemia as High Risk Patients: A Cross-Sectional Survey in Jahrom, Southern, Iran.

Abdolreza Sotoodeh Jahromi,Alireza Yusefi,Hassan Zabetian,Abdolali Sapidkar,Mohammad Kargar,Abbas Ahmadi-Vasmehjani,Mohammad Sadegh Sanie,Farshid Kafilzadeh,Mohammad Hojjat-Farsangi,Saiedeh Erfanian,Abdolhossien Madani,Hossein Hakimelahi,Masoud Ghanei,Somayehsadat Talebnia Jahromi

doi:10.5539/gjhs.v8n9p245

Abstract

Hepatitis E virus (HEV) could be cause of viral hepatitis in the developing countries and cause severe epidemics. According to other studies, blood transfusion as a probable route of HEV infection has been suggested. An infection with hepatitis agents such as HEV causes active liver failure in multi-transfusion patients in particular thalassemia. The purpose of this study determines the seropositivity of anti-HEV antibodies in thalassemia individuals in Jahrom. In a cross-sectional study, sera from 110 thalassemia were collected between 2013 and 2014. Enzyme-linked immunosorbent assay (ELISA) method was performed to detection of anti-HEV antibodies. Individuals’ data were collected such as, demographic and clinical, for statistical analysis. Our results show that 10% and 1.8% of the enrolled patients were HEV Ig-G and Ig-M positive antibodies respectively. In addition, there was statiscally significant difference in age groups for prevalence of anti-HEV Ig-G (P = 0.01). Also the serum levels of liver enzymes such as ALT and AST in the HEV Ig-G and Ig-M positive samples were significantly higher than anti-HEV negative samples. But there were no significant difference between sex and splenectomy with anti-HEV positive samples. The results indicate more study are needed to assess HEV screening of blood products to these patients that those have a probably risk of exposure to HEV especially in higher years old.

Highlights

Hepatitis E virus (HEV) belongs to genus Hepevirus of the Hepeviridae family that a small nonenveloped single-stranded RNA virus (Cheng et al, 2012)
It is noted that HEV infection is a main health concern in developing countries such as Iran because it occur to large epidemic in endemic regions and to sporadic forms in developed regions (Peron, Mansuy, Izopet, & Vinel, 2006)
Transmission of HEV infection occurs by the fecal-oral route and dirty water that plays an important role in transmission route (Peron, Mansuy, Izopet, & Vinel, 2006)

Summary

Introduction

Hepatitis E virus (HEV) belongs to genus Hepevirus of the Hepeviridae family that a small nonenveloped single-stranded RNA virus (Cheng et al, 2012). Infection of hepatitis agents usually leads to benign acute hepatitis, but be fulminant in patients with chronic liver disease (CLD) (Ahmadi Vasmehjani, Javeshghani, Baharlou, Shayestehpour, Mousavinasab, Joharinia, & Enderami, 2015). This virus is the etiologic agent for liver injury in endemic regions of world (Acharya & Panda, 2005). It is noted that HEV infection is a main health concern in developing countries such as Iran because it occur to large epidemic in endemic regions and to sporadic forms in developed regions (Peron, Mansuy, Izopet, & Vinel, 2006). Transmission of HEV infection occurs by the fecal-oral route and dirty water that plays an important role in transmission route (Peron, Mansuy, Izopet, & Vinel, 2006). In high endemic areas, vertical and transfusion of infected blood products, is able to cause this way associated hepatitis E, are other approaches for its www.ccsenet.org/gjhs

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