Sero-epidemiological analysis on hepatitis B among children aged 1-14 years old born to HBsAg positive mother in China, 2014

Abstract

Objective: To analyze the sero-epidemiological features of hepatitis B among children aged 1-14 years old who were born to HBsAg positive mothers. Methods: Based on the results from the hepatitis B national sero-survey in 2014, children aged 1-14 years old born to HBsAg positive mother were involved in this study. Positive rates on HBsAg, anti-HBs, anti-HBc by gender, age, nationality, birth place, residency (urban/rural), region (eastern/central/western) and related factors of HBsAg and anti-HBs for children under research, were analyzed by SPSS 18.0 statistical software. Results: A total of 645 children aged 1-14 years old that born to HBsAg positive mothers were analyzed in the study. Positive rates on HBsAg, anti-HBs, anti-HBc among these children were 3.41% (22/645), 71.94% (464/645) and 7.60% (49/645), respectively. HBsAg positive rates for children aged 1-2 years, 3-4 years, 5-9 years, 10-14 years appeared 1.27% (3/236), 3.23% (6/186), 5.71% (8/140) and 6.02% (5/83), respectively. The anti-HBs positive rates were 85.17% (201/236), 69.35% (129/186), 56.43% (79/140), 66.27% (55/83) while the anti-HBc positive rates were 4.66% (11/236), 5.38% (10/186), 11.43% (16/140) and 14.46% (12/83), respectively. Results from the multifactor logistic analysis showed that birth place, time of the first dose of HepB inoculation were major influencing factors on the positive rates among children with HBsAg. HBsAg positive rate for the children born outside the hospital was higher than those born in the hospital (OR=7.47, 95%CI:1.50-37.25). HBsAg positive rate for children with the first dose of HepB inoculation>24 h after birth, was higher than that inoculation within 24 h after birth (OR=6.21, 95% CI: 2.15-17.99). Conclusions: Some achievements in preventing mother-to-child transmission of hepatitis B had been seen in China. Hospital delivery for pregnant women and timely HepB vaccination with birth-dose for the neonates, remained the key strategy on prevention of HBV vertical transmission.