Abstract
Serine proteinase inhibitor B9(Serpin B9), one member of the protease inhibitor superfamily including human serine proteinase inhibitor 9(PI-9) and rat serine proteinase inhibitor homologous protein SPI-6, is an endogenous protease inhibitor mainly against GrB.Serpin B9 regulate apoptosis, immune reaction, DNA vaccines’ abilities in T lymphocytes, dendritic cells, natural killer cells, neutrophils, mesenchymal stem cells and tumor cells.Study on the function of Serpin B9 could not only facilitate further exploration of the mechanism of immune related diseases, but also provide new theoretical basis for the treatment of tumor and the clinical applicution of stem cells. Key words: Serine proteinase inhibitor; B9; Immune cell
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