SERIES OF 62 CASES OF ACINIC CELL CARCINOMA IN THE ORAL AND MAXILLOFACIAL REGION

Abstract

Objective This study aimed to integrate the clinicopathological and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial regions. Study Design AciCC cases were retrospectively retrieved from 7 pathology centers of three different countries. Results Of a total of 62 cases, females (69.35%) were more affected, with a mean age of 45.96 years. The parotid gland (79.03%) was more involved with an asymptomatic (61.90%) nodule (52.63%). AciCC has four main histopathological patterns - solid, papillary-cystic, microcystic, and follicular - but the association of two patterns was the most common feature (51.28%), with a conventional histological grade (86.66%). Surgical resection (60.00%) was the main treatment choice. Only three cases recurred, while six reported some metastatic lesion. The mean follow-up time was 63.05 months and 2 patients died from the disease. Conclusion Although AciCC lesions have an indolent course in the majority of cases, high histopathological transformation, the presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region. This study aimed to integrate the clinicopathological and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial regions. AciCC cases were retrospectively retrieved from 7 pathology centers of three different countries. Of a total of 62 cases, females (69.35%) were more affected, with a mean age of 45.96 years. The parotid gland (79.03%) was more involved with an asymptomatic (61.90%) nodule (52.63%). AciCC has four main histopathological patterns - solid, papillary-cystic, microcystic, and follicular - but the association of two patterns was the most common feature (51.28%), with a conventional histological grade (86.66%). Surgical resection (60.00%) was the main treatment choice. Only three cases recurred, while six reported some metastatic lesion. The mean follow-up time was 63.05 months and 2 patients died from the disease. Although AciCC lesions have an indolent course in the majority of cases, high histopathological transformation, the presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region.