Abstract
In this prospective cohort study of 250 stable heart failure patients with trimonthly blood sampling, we investigated associations of 17 repeatedly measured cytokines and cytokine receptors with clinical outcome during a median follow-up of 2.2 (25th-75th percentile, 1.4-2.5) years. Sixty-six patients reached the primary end point (composite of cardiovascular mortality, heart failure hospitalization, heart transplantation, left ventricular assist device implantation). Repeatedly measured levels of 8 biomarkers correlated with clinical outcomes independent of clinical characteristics. Rates of change over time (slopes of biomarker evolutions) remained independently associated with outcome for 15 biomarkers. Thus, temporal patterns of cytokines and cytokine receptors, in particular tumour necrosis factor ligand superfamily member 13B and interleukin-1 receptor type 1, might contribute to personalized risk assessment.
Highlights
RESUME Dans cette etude prospective d’une cohorte de 250 patients atteints d’ cardiaque stable, soumis à un prelèvement sanguin trimestriel, nous avons etudie les associations entre 17 cytokines et recepteurs aux cytokines mesures de façon repetee et les consequences cliniques au cours d’un suivi median de 2.2 annees (25e-75e percentile, 1,4-2,5)
Temporal patterns of several cytokines and cytokine receptors were associated with adverse events in 250 stable patients with heart failure (HF), even after adjustment for clinical factors
In a recent meta-analysis, concentrations of tumour necrosis factor-a, IL-6, IL-1b, and Creactive protein (CRP) were significantly higher in chronic HF patients than in control participants, and serum IL-6 predicted mortality.[7]
Summary
RESUME Dans cette etude prospective d’une cohorte de 250 patients atteints d’ cardiaque stable, soumis à un prelèvement sanguin trimestriel, nous avons etudie les associations entre 17 cytokines et recepteurs aux cytokines mesures de façon repetee et les consequences cliniques au cours d’un suivi median de 2.2 annees (25e-75e percentile, 1,4-2,5). Soixante-six patients ont atteint le principal critère d’evaluation (indice composite prenant en compte la mortalite cardiovasculaire, l’hospitalisation pour insuffisance cardiaque, la transplantation cardiaque, l’implantation d’un dispositif d’assistance ventriculaire gauche). Les. Corresponding author: Dr Isabella Kardys, Erasmus MC, University Medical Center Rotterdam, Department of Cardiology, Room Na-316, PO Box 2040, 3000 CA Rotterdam, The Netherlands. Measured a broad range of cytokines and cytokine receptors repeatedly with a multiplex assay in patients with stable HF, and investigated the association between their temporal patterns and clinical outcome
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