Abstract
Sensitivity of antigen detection by B cells correlates with high-affinity binding. This paradigm does not appear to hold for the T-cell receptor (TCR), which is able to bind its ligand — peptide in the context of major histocompatibility complex (MHC) — with low affinity. Here, Salvatore Valitutti and Antonio Lanzavecchia propose that the efficiency of T-cell antigen recognition is dependent upon optimal kinetics of the TCR—peptide—MHC interaction, allowing serial engagements and triggering of many TCRs by a few peptide—MHC complexes.
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