Abstract
Patients with diabetes mellitus (DM) are at increased risk for atherosclerosis-related events compared tonon-DM (NDM) patients. With an expected worldwide epidemic of DM, early detection of anatomic andfunctional coronary atherosclerotic changes is gaining attention. To improve our understanding of earlyatherosclerosis development, we studied a swine model that gradually developed coronary atherosclerosis. Interestingly, optical coherence tomography, near-infrared spectroscopy (NIRS), vascular function, and histology demonstrated no differences between development of early atherosclerosis in fast-food-fed (FF) DM swine and that in FF-NDM swine. Coronarycomputed tomography angiography did not detect early atherosclerosis, but optical coherence tomography andnear-infrared spectroscopy demonstrated coronary atherosclerosis development in FF-DM and FF-NDM swine.
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