Abstract
In a culture of Chang's human liver cells chronically infected with 6BC psittacosis virus a series of changes occurred over a period of one year which was marked by the selection of first, a more virulent virus variant and then a more resistant cell variant. In addition to these population changes, two other factors which may have contributed to the maintenance of the chronic state of infection were (1) the multiplication of infected cells which sometimes resulted in the emergence of uninfected daughter cells after cell division, and (2) the apparent ability of some infected cells to overcome infection, even after the formation of a well-developed inclusion body, either by release or dissolution of the virus. The greater virulence of the variant virus over that of the parent for Chang's cells was correlated with a greater virulence for mice.
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