Serial Changes in Serum ACE 2 and Plasma Ang (1-7) Concentration of Acute Heart Failure Syndrome Patients with Standard Therapy

Abstract

Recently the existence of the ACE2-Ang(1-7)-Mas receptor-axis and the organ-protective effect by activating this axis have been revealed. We reported that serum ACE2 concentration level is higher and plasma Ang(1-7) concentration level is lower in AHFS-patients than healthy volunteers. Although there are no reports about its serial changes. To evaluate the serial changes of serum ACE2 concentration and plasma Ang(1-7) concentration for hospitalized AHFS-patients. Seventy-three patients hospitalized with acute heart failure at our institute between Nov. 2012 and May 2014. Plasma renin activity, serum ACE, plasma Ang II, serum ACE2, plasma Ang(1-7), and plasma aldosterone concentrations were measured immediately after the patient were able to sit up, and then one and three months after the onset of the standard therapy then evaluated the serial changes. Average age was 63±14 years old, 22% male, and the cause of acute AHFS was 29 ischemic heart disease, 43 non-ischemic heart disease. There were no serial changes in plasma renin activity, serum ACE, plasma Ang II, serum ACE2 and plasma aldosterone concentration. Plasma Ang(1-7) concentration significantly increased (2.43±1.18 ng/ml vs 3.02±1.98 ng/ml vs 3.35±2.01 ng/ml, p±0.05). Plasma Ang(1-7) concentration increased in AHFS patients with standard therapy.