Serial Assessment of Tricuspid Annular Plane Systolic Excursion Is Associated with Death or Lung Transplant in Children with Pulmonary Arterial Hypertension

Abstract

Pediatric pulmonary arterial hypertension (PAH) may be classified as primary/idiopathic or may be associated with congenital heart (CHD) or lung disease.1 Right ventricular (RV) function over time determines morbidity and mortality.1 Tricuspid annular plane systolic excursion (TAPSE), a measure of RV longitudinal function, is associated with outcomes in adults with PAH,2 but serial pediatric data are limited and are mostly from a single cohort.3,4 Our prior cross-sectional work established that among several echocardiographic parameters, TAPSE best reflects RV stroke work, a measure of RV efficiency in relation to its loading, which is associated with clinical outcomes.