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Abstract
Edema is the main symptom of nephrotic syndrome associated to minimal change disease (MCD). Besides the increase in glomerular permeability, possibly induced by a circulating permeability factor,1 an increase in systemic vascular permeability could participate in the constitution of edema.
Highlights
Edema is the main symptom of nephrotic syndrome associated to minimal change disease (MCD)
MCD Serum Induces an Increase in Human Umbilical Vein Endothelial Cell Permeability In Vitro First, we evaluated the effect of MCD serum on the global permeability of human umbilical vein endothelial cells (HUVECs) via the xCELLigence Real Time Cell Analyzer system (ACEA Biosciences, Inc., San Diego, CA) (Figure 1a)
We observed a significant decrease in the impedance, reflecting an increased permeability, with sera from MCD patients compared to sera from healthy volunteers (HVs) (Figure 1b)
Summary
Edema is the main symptom of nephrotic syndrome associated to minimal change disease (MCD). We demonstrated an increased permeability of HUVEC in vitro after stimulation by sera of patients with MCD, probably restricted to LMW molecules such as sodium.
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