Sequential use of epigenetic therapy helps to shorten duration of classic chemotherapy in the treatment of ovarian cancer and minimizes damage to normal tissue

Abstract

Objective: Combined usage of epigenetic drugs with classic chemotherapy is effective against ovarian cancer, but has adverse effects on normal tissues. We aim to determine the optimal sequence of classic chemotherapy with epigenetic drugs that target ovarian cancer and limit toxicity to normal cells. We also investigate whether epigenetic treatment can shorten the exposure to classic chemotherapy, as it is nonspecific to all rapidly dividing cells.