Abstract

A simplified synthesis of symmetrical 1,4-disubstitued 1,3-butadiynes was developed using a sequential two-step process combining a typical Sonogashira coupling with a Glaser coupling. The Sonogashira reaction coupled arylbromide and trimethylsilylacetylene. In the second step, a Glaser coupling reaction was performed using the crude trimethyl(arylethynyl)silane product from the previous Sonogashira coupling in a basic solvent; the Glaser coupling proceeded to completion without the addition of extra Pd or Cu catalysts. The catalytic amount of metal (Cu and Pd) in the second step was substantially less than that used in a typical Glaser coupling reaction.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.