Abstract
The sequential simplex method is used in a constrained simplex mixture space to optimize the liquid chromatographic separation of five neutral organic solutes: uracil, phenol, acetophonenone, methylbenzoate, and toluene. The mobile phase composition is varied while column temperature, mobile phase flow-rate, and sample concentration are held constant. The chromatographic response function and the total analysis time are used in an overall desirability function to direct the progress of the sequential simplex optimization.
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