Abstract
To develop guidelines for the timing and interpretation of thyroglobulin (TG) measurements in patients with well differentiated thyroid cancer, we performed 131I whole body scans and uptakes with simultaneous serum TG and TSH determinations in 49 patients with this disease. In 15 patients, TG measurements were obtained initially while the patient was receiving T3 therapy and then were repeated serially within a period of up to 35 days after T3 withdrawal. In 9 patients with functioning thyroid tissue, the changes in TG paralleled the changes in TSH levels. Before stopping T3, TG measurements were a poor indicator of function, since 14 of 15 patients had suppressed TG levels (<10 ng/ml). After 2 weeks off T3, TG increased in all 5 patients with scan evidence of metastases, in 2 of 4 subjects with residual thyroid bed uptake, and in 2 of 6 patients with no uptake. In 23 patients, both the scan and serum TG measurements were performed 2 and 4 weeks after stopping T3. At 4 weeks, compared to 2 weeks, TG level...
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