Abstract
51 sequential determinations of cerebrospinal fluid (CSF) lactate dehydrogenase (LDH) isoenzyme in 5.5% polyacrylamide gel were performed in 26 samples from patients with brain tumors. The assay was made prior to and after treatment. 26 untreated patients demonstrated elevated total LDH activity. 17 of 26 patients showed altered isoenzyme pattern. Disappearance of LDH5, decrease of LDH4 and relative increase of LDH2 were accompanied by improvement in clinical status in 15 of 26 patients. This suggests the utility of the CSF LDH isoenzyme pattern to monitor the clinical status of treatment in brain tumors.
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